Usefulness of movement time in the assessment of Parkinson's disease
Identifieur interne : 000900 ( Main/Corpus ); précédent : 000899; suivant : 000901Usefulness of movement time in the assessment of Parkinson's disease
Auteurs : Mario Zappia ; Rita Montesanti ; Rosanna Colao ; Aldo QuattroneSource :
- Journal of Neurology [ 0340-5354 ] ; 1994-09-01.
Abstract
Abstract: Reaction time (RT) and movement time (MT) are reported to be delayed in Parkinson's disease (PD), but their clinical utility and relationship with clinical findings is still uncertain. We investigated RT and MT in 22 PD patients at baseline conditions and following acute oral trials of levodopa and biperiden, an anticholinergic drug. At baseline conditions, RT and MT of PD patients were abnormally delayed compared with those of 16 normal control subjects. Both RT and MT were longer in more severely affected patients compared with the mild PD patients; in the mild PD patients with asymmetrical signs both responses were longer on the more affected side. Bradykinesia was the clinical symptom that best correlated with the objective measurements, with a stronger correlation for MT than for RT. The oral administration of levodopa significantly improved both the responses, whereas biperiden was ineffective. The magnitude of RT and MT improvement after levodopa differed; MT improvement was related to PD severity, whereas RT improvement was not. These results suggest that MT, rather than RT, is an objective, simple, and reliable tool to evaluate bradykinesia and its levodopa-induced modifications in PD.
Url:
DOI: 10.1007/BF00873517
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Campanella, 1-88100, Catanzaro, Italy</mods:affiliation></affiliation></author><author><name sortKey="Colao, Rosanna" sort="Colao, Rosanna" uniqKey="Colao R" first="Rosanna" last="Colao">Rosanna Colao</name><affiliation><mods:affiliation>Istituto di Scienze Neurologiche, Policlinico “Mater Domini”, Via T. Campanella, 1-88100, Catanzaro, Italy</mods:affiliation></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation><mods:affiliation>Istituto di Scienze Neurologiche, Policlinico “Mater Domini”, Via T. 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Campanella, 1-88100, Catanzaro, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology</title><title level="j" type="abbrev">J Neurol</title><idno type="ISSN">0340-5354</idno><idno type="eISSN">1432-1459</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1994-09-01">1994-09-01</date><biblScope unit="volume">241</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="543">543</biblScope><biblScope unit="page" to="550">550</biblScope></imprint><idno type="ISSN">0340-5354</idno></series><idno type="istex">E2DFF90F7FB6F2B75EF271667FF99ACFF3CFA7B4</idno><idno type="DOI">10.1007/BF00873517</idno><idno type="ArticleID">Art6</idno><idno type="ArticleID">BF00873517</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0340-5354</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Reaction time (RT) and movement time (MT) are reported to be delayed in Parkinson's disease (PD), but their clinical utility and relationship with clinical findings is still uncertain. We investigated RT and MT in 22 PD patients at baseline conditions and following acute oral trials of levodopa and biperiden, an anticholinergic drug. At baseline conditions, RT and MT of PD patients were abnormally delayed compared with those of 16 normal control subjects. Both RT and MT were longer in more severely affected patients compared with the mild PD patients; in the mild PD patients with asymmetrical signs both responses were longer on the more affected side. Bradykinesia was the clinical symptom that best correlated with the objective measurements, with a stronger correlation for MT than for RT. The oral administration of levodopa significantly improved both the responses, whereas biperiden was ineffective. The magnitude of RT and MT improvement after levodopa differed; MT improvement was related to PD severity, whereas RT improvement was not. These results suggest that MT, rather than RT, is an objective, simple, and reliable tool to evaluate bradykinesia and its levodopa-induced modifications in PD.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>Mario Zappia</name><affiliations><json:string>Istituto di Scienze Neurologiche, Policlinico “Mater Domini”, Via T. Campanella, 1-88100, Catanzaro, Italy</json:string></affiliations></json:item><json:item><name>Rita Montesanti</name><affiliations><json:string>Istituto di Scienze Neurologiche, Policlinico “Mater Domini”, Via T. Campanella, 1-88100, Catanzaro, Italy</json:string></affiliations></json:item><json:item><name>Rosanna Colao</name><affiliations><json:string>Istituto di Scienze Neurologiche, Policlinico “Mater Domini”, Via T. Campanella, 1-88100, Catanzaro, Italy</json:string></affiliations></json:item><json:item><name>Aldo Quattrone</name><affiliations><json:string>Istituto di Scienze Neurologiche, Policlinico “Mater Domini”, Via T. 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Bradykinesia was the clinical symptom that best correlated with the objective measurements, with a stronger correlation for MT than for RT. The oral administration of levodopa significantly improved both the responses, whereas biperiden was ineffective. The magnitude of RT and MT improvement after levodopa differed; MT improvement was related to PD severity, whereas RT improvement was not. 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Campanella</Street><Postcode>1-88100</Postcode><City>Catanzaro</City><Country>Italy</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>Reaction time (RT) and movement time (MT) are reported to be delayed in Parkinson's disease (PD), but their clinical utility and relationship with clinical findings is still uncertain. We investigated RT and MT in 22 PD patients at baseline conditions and following acute oral trials of levodopa and biperiden, an anticholinergic drug. At baseline conditions, RT and MT of PD patients were abnormally delayed compared with those of 16 normal control subjects. Both RT and MT were longer in more severely affected patients compared with the mild PD patients; in the mild PD patients with asymmetrical signs both responses were longer on the more affected side. Bradykinesia was the clinical symptom that best correlated with the objective measurements, with a stronger correlation for MT than for RT. The oral administration of levodopa significantly improved both the responses, whereas biperiden was ineffective. The magnitude of RT and MT improvement after levodopa differed; MT improvement was related to PD severity, whereas RT improvement was not. These results suggest that MT, rather than RT, is an objective, simple, and reliable tool to evaluate bradykinesia and its levodopa-induced modifications in PD.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Parkinson's disease</Keyword><Keyword>Reaction time</Keyword><Keyword>Movement time</Keyword><Keyword>Biperiden</Keyword><Keyword>Levodopa</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Usefulness of movement time in the assessment of Parkinson's disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Usefulness of movement time in the assessment of Parkinson's disease</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Mario</namePart><namePart type="family">Zappia</namePart><affiliation>Istituto di Scienze Neurologiche, Policlinico “Mater Domini”, Via T. Campanella, 1-88100, Catanzaro, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rita</namePart><namePart type="family">Montesanti</namePart><affiliation>Istituto di Scienze Neurologiche, Policlinico “Mater Domini”, Via T. Campanella, 1-88100, Catanzaro, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rosanna</namePart><namePart type="family">Colao</namePart><affiliation>Istituto di Scienze Neurologiche, Policlinico “Mater Domini”, Via T. Campanella, 1-88100, Catanzaro, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Aldo</namePart><namePart type="family">Quattrone</namePart><affiliation>Istituto di Scienze Neurologiche, Policlinico “Mater Domini”, Via T. Campanella, 1-88100, Catanzaro, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper"></genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1993-06-07</dateCreated><dateIssued encoding="w3cdtf">1994-09-01</dateIssued><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Abstract: Reaction time (RT) and movement time (MT) are reported to be delayed in Parkinson's disease (PD), but their clinical utility and relationship with clinical findings is still uncertain. We investigated RT and MT in 22 PD patients at baseline conditions and following acute oral trials of levodopa and biperiden, an anticholinergic drug. At baseline conditions, RT and MT of PD patients were abnormally delayed compared with those of 16 normal control subjects. Both RT and MT were longer in more severely affected patients compared with the mild PD patients; in the mild PD patients with asymmetrical signs both responses were longer on the more affected side. Bradykinesia was the clinical symptom that best correlated with the objective measurements, with a stronger correlation for MT than for RT. The oral administration of levodopa significantly improved both the responses, whereas biperiden was ineffective. The magnitude of RT and MT improvement after levodopa differed; MT improvement was related to PD severity, whereas RT improvement was not. 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